

There are more point of no returns than you think. I suggest you do not read this unless you've already met.

Mass Fusion is a major turning point in faction relations between Institute and Brotherhood. Fallout 4 Main Quests Points of No Return and How Far You Can Go I've tried to document the quests that turn factions against one another. If you side with one you will be at war with the other. The brotherhood and railroad Battle of bunker hill also plays a large role with these two. If that quest triggers your forced to go brotherhood, railroad or institute. The Minutemen you cannot trigger battle of bunker hill. The only way you can become enemies with the Railroad is to kill.

The Institute point of no return is Mass Fusion where you will become enemies with the BoS.
